Table 5 Interactions between PSE and genetic variants on child ADHD risk
PSE | Genotype | Cases, N(%) | Controls, N(%) | OR(95% CI) | P mul | AP(95% CI) | RERI(95% CI) |
|---|---|---|---|---|---|---|---|
ADRA2A rs553668 | |||||||
No | AA | 26(16.25) | 61(27.11) | 1 | 0.003 | 0.48(0.09–0.87) | 1.88(0.06–4.12) |
Yes | AA | 14(8.75) | 23(10.22) | 1.36(0.58–3.22) | |||
No | AG + GG | 76(47.50) | 115(51.11) | 1.65(0.93–2.90) | |||
Yes | AG + GG | 44(27.50) | 26(11.56) | 3.54(1.73–7.25) | |||
DRD2 rs1124491 | |||||||
No | AA | 7(4.27) | 27(12.16) | 1 | 0.175 | −0.55(−1.84–0.73) | −3.34(−11.42–4.74) |
Yes | AA | 99(60.36) | 145(65.32) | 5.34(1.64–4.46) | |||
No | AG + GG | 6(3.66) | 6(2.70) | 3.99(1.46–0.89) | |||
Yes | AG + GG | 52(31.71) | 44(19.82) | 6.04(2.07–7.65) | |||
SLC6A4 rs6354 | |||||||
No | TT | 74(44.31) | 147(63.91) | 1 | 0.234 | −0.80(−2.42–0.82) | −1.37(−3.39–0.65) |
Yes | TT | 44(26.35) | 39(16.96) | 2.13(1.20–3.78) | |||
No | TG + GG | 34(20.36) | 32(13.91) | 1.97(1.10–3.52) | |||
Yes | TG + GG | 15(8.98) | 12(5.22) | 1.79(0.75–4.28) | |||
