Figure 2
From: Circulating CD56bright NK cells inversely correlate with survival of melanoma patients
Phenotypic characterization of CD56bright NK cells by flow cytometry. (A) Representative histograms of the expression level (Median Fluorescent Intensity, MFI) of CD11a, CD38 and CD95 on CD56bright NK cells. The histograms show overlays; patient LAU975 (grey) and healthy donor 7 (black). (B) Summary histograms of the expression levels (MFI) of CD11a, CD38 and CD95. (C) Distribution of the expression levels (MFI) of CD11a, CD38 and CD95 from patients with late stage (III/IV) melanoma and healthy donors. (D) Summary histograms of the expression levels (MFI) of NKp46, NKG2D and NKG2A. (E) Distribution of the expression levels (MFI) of NKp46, NKG2D and NKG2A from patients with late stage (IIII/V) melanoma and healthy donors. (F) Frequencies of regulatory T cells (CD25hiFoxP3+CD127−) in the blood of melanoma patients before vaccination (n = 21) correlating with the expression levels of CD38 (MFI) on CD56bright NK cells (n = 21) from the same patients. ns not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
