Figure 7 | Scientific Reports

Figure 7

From: The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism

Figure 7

p53-TMGST ubiquitination mediated by chaperones Hsp70, Hsp90, and their variants with shorter, disordered C-terminal sequences. (a) Top, sequence of the full-length C-terminal region of Hsp70 and its shorter variant. Bottom, western blot of a ubiquitination experiment using an anti-p53 antibody. (b) Top, sequence of the full-length C-terminal region of Hsp90 and its shorter variant. Bottom, western blot of a ubiquitination experiment using an anti-p53 antibody.

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