Table 4 The effects of decitabine dosage and treatment time on decitabine incorporation in DNA and DNA hypomethylation.
Decitabine dose (µM) | 24-h Study | 48-h Study | ||||||
|---|---|---|---|---|---|---|---|---|
Decitabine incorporation (fmol/mg DNA) | DNA methylation | Decitabine incorporation (fmol/mg DNA) | DNA methylation | |||||
HL-60 | U937 | HL-60 | U937 | HL-60 | U937 | HL-60 | U937 | |
0.000 | 0.000 | 0.000 | 4.86 | 4.89 | 0.000 | 0.000 | 4.86 | 4.89 |
0.100 | 88.0 | 46.0 | 4.21 | 4.47 | 96.0 | 65.0 | 4.10 | 4.23 |
0.500 | 120 | 64.0 | 3.66 | 4.16 | 132 | 95.0 | 3.45 | 3.99 |
1.00 | 133 | 94.0 | 3.16 | 3.45 | 155 | 114 | 2.77 | 3.06 |
10.0 | 136 | 96.0 | 2.88 | 3.25 | 172 | 146 | 2.04 | 2.70 |
