Table 1 Subgroup analysis of molecular diagnostics results for diagnosing TB.

From: Accuracy of Commercial Molecular Diagnostics for the Detection of Pulmonary Tuberculosis in China: A Systematic Review

Molecular diagnostics

Sputum Smear

No. of studies

Pooled Sensitivity [95% CI]

Pooled Specificity [95% CI]

①Xpert MTB/RIF

Positive

2*,a

1.00 [0.91, 1.00] 0.98 [0.94, 0.99]

—

Negative

4*,b

0.75 [0.52, 0.90]

0.94 [0.81, 0.98]

②LAMP

Positive

2*,a

0.92 [0.87, 0.96] 0.97 [0.93, 0.99]

 

Negative

3*,c

0.67 [0.49, 0.81]

0.96 [0.86, 0.99]

③LPA

Positive

0

—

—

Negative

1*,a

0.87 [0.84, 0.90]

0.94 [0.92, 0.95]

④CPA

Positive

1*,a

0.94 [0.91, 0.96]

 

Negative

1*,a

0.82 [0.75, 0.88]

0.90 [0.87, 0.92]

⑤SAT-TB

Positive

1*,a

0.85 [0.81, 0.88]

 

Negative

1*,a

0.57 [0.52, 0.62]

0.59 [0.56, 0.62]

⑥PCR

Positive

1*,a

0.95 [0.87, 0.99]

 

Negative

1*,a

0.61 [0.36, 0.83]

1.00 [0.92, 1.00]

  1. *,aThe sensitivity and specificity of original studies were retained when the number of studies were less than 3.
  2. *,bBivariate random effect model to estimate the pooled sensitivity and specificity.
  3. *,cUnivariate random effect model to calculate the pooled sensitivity and specificity separately.
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