Figure 5 | Scientific Reports

Figure 5

From: Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice

Figure 5

JuA maintains basal levels of CREB signaling. (A) Representative immunoblots of hippocampus extracts from WT, WT + SD, WT + JuA + SD, APP/PS1, APP/PS1 + SD and APP/PS1 + JuA + SD groups. (B) Quantification of the immunoblots showing significant decrease in pCREB levels in WT + SD and APP/PS1 + SD group and decrease tCREB levels in APP/PS1 + SD mice, while JuA treatment to sleep deprived WT and APP/PS1 mice maintains the levels of pCREB and tCREB (C) pCREB/tCREB ratio is unchanged for APP/PS1 but changed for WT. Each value represents the mean ± SEM; *p < 0.05, **p < 0.01; two-way ANOVA followed by LSD post hoc test.

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