Figure 6 | Scientific Reports

Figure 6

From: Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice

Figure 6

JuA prevents sleep loss-induced spatial memory deficit. (A) Sample traces of activity of mice in the MWM. (B) The WT + SD and APP/PS1 + SD spent less time in target quadrant, while APP/PS1 + JuA + SD group shows more time spent in the target quadrant. (C) Number of platform crossings of WT + JuA + SD and APP/PS1 + JuA + SD group differs from WT + SD and APP/PS1 + SD group respectively, but is comparable to their respective Ctrl animals (n = 14 for WT and WT + SD, n = 13 for WT + JuA and WT + JuA + SD, n = 15 for APP/PS1 and 12 for APP/PS1 + SD, APP/PS1 + JuA and APP/PS1 + JuA + SD). Each value represents the mean ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001; two-way ANOVA followed by LSD post hoc test.

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