Figure 4 | Scientific Reports

Figure 4

From: p5RHH nanoparticle-mediated delivery of AXL siRNA inhibits metastasis of ovarian and uterine cancer cells in mouse xenografts

Figure 4

Treatment with p5RHH-siAXL significantly reduces metastasis of ARK1 xenografts. Graphs depicting the (A) number of peritoneal tumor nodules and (B) total tumor weight per mouse treated with either p5RHH-siControl (n = 5) or p5RHH-siAXL (n = 5). (C) qRT-PCR was performed on tumors treated with p5RHH-siControl or p5RHH-siAXL and AXL mRNA expression was assessed. (D) Representative images of AXL and ki67 immunohistochemistry of tumor samples from vehicle, p5RHH-siControl, or p5RHH-siAXL mice at 40X magnification. Data are represented as mean +/− SD. *P < 0.05, **P < 0.01, ***P < 0.001 by unpaired t-test.

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