Figure 1
From: Oligoclonal immunoglobulin repertoire in biliary remnants of biliary atresia
Abundant B cells are present in biliary remnants of iBA and BASM infants as compared to choledochal cyst cases. (a) High-powered field images demonstrating the densest areas of Pax5 positive B cells in 3 iBA, BASM, and CC cases. (b) Quantification of Pax5 positive B cells per mm2 of tissue (whole slide) and per the densest high-powered field (40x magnification) for iBA, BASM, and CC cases. (c) Average relative RT-PCR quantification of the B cell markers CD19, Pax5, and CD20 demonstrated no significant difference in expression levels between iBA and BASM biliary remnants (p > 0.05). There was no significant difference in relative quantification of CD19 and Pax5 between the remnants and their paired local lymph nodes (p > 0.05), however, CD20 expression was significantly lower in biliary remnants (p = 0.01).
