Figure 4
From: Effect of Spheroidal Age on Sorafenib Diffusivity and Toxicity in a 3D HepG2 Spheroid Model
Transmission electron micrographs of HepG2 spheroids after (a) 6 days post-seeding and (b) 15 days post-seeding with organo-typic bile canaliculi (BC). Scale bars, 2 µm. (c) Activity of CYP 3A4 of HepG2 spheroids over time and secretion of (d) albumin and (e) urea of HepG2 spheroids over a cultivation period of 18 days. Error bars indicate ± SD (n = 3).
