Figure 6

In vivo dasatinib treatment decreases lung and distant organ metastases. (A) Primary tumor weight and (B) number of lung metastases in syngeneic mice treated with Dasatinib, n = 9 (10 mg/kg: solid shapes, 20 mg/kg: empty shapes) or vehicle, n = 10. (C) H&E staining of the lung sections with and without Dasatinib treatment. (D) Images of sites of distant metastases from DMSO treated animals (black arrows indicate metastases). (E) Immunohistochemistry of intratumoral p-Src levels in the DMSO and Dasatinib treated mice.