Figure 8
From: Low survival rate and muscle fiber-dependent aging effects in the McArdle disease mouse model
Histological and biochemical determination of glycogen in different muscles and ages of McArdle (McA) mice. (A) PAS staining of soleus, gastrocnemius, extensor digitorum longus (EDL), tibialis anterior (TA) and quadriceps in 8-week-old wild-type (WT) and heterozygous (HTZ) mice as well as in 8, 35 and 70-week-old McA mice. All the scale bars correspond to 150 µm. PAS staining was markedly increase in all sections from McA mice. (B) Biochemical determination of glycogen in TA, quadriceps and gastrocnemius of 8 and 70 wo WT and McA mice. N indicates the number of muscles used to calculate the mean values. Error bars correspond to SD. The non-parametric Kruskal-Wallis One-Way ANOVA with multiple comparisons test (Dunn’s test) was used for statistical analyses. Symbols: *p < 0.05.
