Figure 5 | Scientific Reports

Figure 5

From: The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice

Figure 5

Messenger RNA expression of prooxidative genes (NOX1, NOX2, NOX4), antioxidative genes (SOD1, SOD2, SOD3, GPx1, HO-1, Catalase) and of genes coding for intracellular regulatory proteins involved in aging (SIRT1, SIRT6, FOXO1) in aged wild-type and M1R−/− mice. Expression of NOX2 was significantly increased in aged M1R−/− mice. In contrast, the antioxidative redox genes, SOD1, GPx1 and HO-1, showed reduced expression levels in aged M1R−/− mice. Data are presented as mean ± SD (n = 8 per genotype; *p < 0.05; **p < 0.01; ****p < 0.0001).

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