Table 1 Results of association analyses of gout.

SNP	Chr	Allele 1/2^a	Stage	Cases				Controls				Additive^b		Dominant^b		Recessive^b		P_het
SNP	Chr	Allele 1/2^a	Stage	11	12	22	RAF	11	12	22	RAF	P-value	Risk allele OR (95% CI)	P-value	Risk allele OR (95% CI)	P-value	Risk allele OR (95% CI)	P_het
rs2231142	4	T/G	Discovery	82	181	110	0.46	630	2885	3200	0.31	4.25e-18	2.00	5.27e-11	2.18	2.66e-15	3.00	0.9644
			Follow-up	78	197	109	0.46	696	3202	3538	0.31	1.498e-18	1.99	2.86e-13	2.366	2.96e-12	2.65
			Combined^c	160	378	219	0.46	1326	6087	6738	0.31	5.06e-35	2.00	1.10e-22	2.27	6.50e-26	2.82
rs4148155	4	G/A	Discovery	82	181	110	0.46	633	2889	3195	0.31	5.49e-18	2.00	6.27e-11	2.17	3.16e-15	2.99	0.9893
			Follow-up	79	197	109	0.46	702	3204	3536	0.31	8.593e-19	2.00	2.65e-13	2.37	1.29e-12	2.68
			Combined^c	161	378	219	0.46	1335	6093	6731	0.31	3.74e-35	2.00	1.21e-22	2.27	3.29e-26	2.83
rs2725211	4	T/C	Discovery	48	153	172	0.33	386	2418	3900	0.24	3.42e-09	1.64	8.52e-06	1.63	9.38e-09	2.69	0.9417
			Follow-up	45	168	172	0.34	426	2764	4244	0.24	3.78e-09	1.62	1.22e-06	1.69	9.96e-07	2.35
			Combined^c	93	321	344	0.33	812	5182	8144	0.24	6.88e-17	1.63	4.75e-11	1.66	5.43e-14	2.52
rs2905274	7	A/G	Discovery	12	80	279	0.14	44	1027	5640	0.083	3.91e-08	1.87	2.46e-06	1.84	4.19e-06	5.21	0.0041
			Follow-up	5	71	306	0.11	58	1231	6138	0.091	0.26	1.15	0.34	1.14	0.2829	1.69
			Combined^c	17	151	585	0.12	102	2258	11778	0.087	1.46e-06	1.50	4.81e-05	1.46	1.42e-05	3.50

We analyzed 758 gout cases (in the GWAS and in replication) and 14,166 controls (6,721 in the GWAS and 7,445 in replication). Chr., chromosome; RAF, risk allele frequency. ^aAllele 1, risk allele; allele 2, non-risk allele. ^bP values and ORs were calculated by logistic regression analysis, with age, gender, and 10 principal components as covariates. Non-risk alleles were considered as references in the three genetic models: additive, 1 versus 2; recessive, 11 versus 12 + 22; dominant, 11 + 12 versus 22. Heterogeneity across the two stages was examined by Cochran Q test under a genetic model which provided the minimum P value in the screening stage. ^cORs and P values were calculated using the Mantel-Haenszel fixed-effects model.

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