Figure 1

Schematic illustration of melanosome transport in a melanophore. A melanosome (black circle) is transported by multiple dynein motors (grey) along a microtubule (pink) in a melanophore. During the run at a velocity v, the force (F) generated by motors is equal to the drag force (Γv), where Γ is the friction coefficient of the melanosome. Addition of hormone (epinephrine) caused melanosomes to aggregate in the centre of the cell (bottom). Individual melanosomes could be tracked under a microscope. The schematic was created by the authors.