Figure 7
From: Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates
Effect of PI3K/mTOR/IGF/AKT inhibitors on U87 mg spheroidal aggregates undergoing electrotaxis. 24 h hours after dcEF (stim) or controls without dcEF (CTL) (a) 24 h U87 mg data without inhibitor compounds, redisplayed from Fig. 2d; (b) LY294002 (2 μM) *p = 0.0269 (CTL, n = 10; STIM, n = 13); (c) BEZ235 (25 nM) *p = 0.0306 (CTL, n = 14; STIM, n = 14); (d) LY294002 (20 μM) **p = 0.0015 (CTL, n = 9; STIM, n = 12); (e) BEZ235 (250 nM). (CTL, n = 8; STIM, n = 17); (f) CZC24832 (1 μM). (CTL, n = 14; STIM, n = 26); (g) Rapamycin (100 nM) (CTL, n = 15; STIM, n = 15); (h) KU-0063794 (2.5 μM) (CTL, n = 13; STIM, n = 15); (i) MK-2206 (2 μM) (CTL, n = 8; STIM, n = 16); (j) OSI-906 (1 μM) *p = 0.0479 (CTL, n = 16; STIM, n = 13); ns = not significant; Two-way ANOVA, Holm-Sidak post-hoc.
