Figure 5
From: Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation
Gene expression profiling of SERPINB2-depleted hBMSC−Bone cells under osteogenic conditions. (a) Hierarchical clustering of SERPINB2-depleted hBMSC−Bone cells compared to scramble-siRNA transfected control cells, based on differentially expressed mRNA transcripts. The expression level of each gene in each condition is depicted according to the color scale shown. (b) Pie chart illustrating the distribution of top pathway designations for the de-regulated genes in SERPINB2-depleted hBMSC−Bone cells. (c) The expression levels of selected genes from the microarray data was validated using qRT-PCR in SERPINB2-depleted compared to Scrambled siRNA-transfected control hBMSC−Bone. Data are presented as the means ± SD from two independent experiments, n = 6; ***p < 0.0005.
