Table 3 The proteins in the 2nd extended PPI network involved in the KEGG pathways of alcoholism, amphetamine addiction, and cocaine addition.

From: Construction and Analysis of Protein-Protein Interaction Network of Heroin Use Disorder

KEGG pathway

Name

Description

Alcoholism

ARAF

V-raf murine sarcoma 3611 viral oncogene homolog

Alcoholism

ATF2

Activating transcription factor 2

Alcoholism

BRAF

V-raf murine sarcoma viral oncogene homolog B1

Alcoholism

CREB1

cAMP responsive element binding protein 1

Alcoholism

CREB5

cAMP responsive element binding protein 5

Alcoholism

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

Alcoholism

HDAC1

Histone deacetylase 1

Alcoholism

HDAC2

Histone deacetylase 2

Alcoholism

HDAC3

Histone deacetylase 3

Alcoholism

HIST2H2BE

Histone cluster 2, H2be

Alcoholism

HRAS

v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Alcoholism

MAPK1

Mitogen-activated protein kinase 1

Alcoholism

MAP2K1

Mitogen-activated protein kinase kinase 1

Alcoholism

MAPK3

Mitogen-activated protein kinase 3

Alcoholism

RAF1

V-raf-1 murine leukemia viral oncogene homolog 1

Alcoholism

SOS1

Son of sevenless homolog 1 (Drosophila)

Amphetamine

ATF2

Activating transcription factor 2

Amphetamine

CREB1

cAMP responsive element binding protein 1

Amphetamine

CREB5

cAMP responsive element binding protein 5

Amphetamine

FOS

FBJ murine osteosarcoma viral oncogene homolog

Amphetamine

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

Amphetamine

JUN

Jun proto-oncogene

Amphetamine

HDAC1

Histone deacetylase 1

Cocaine

ATF2

Activating transcription factor 2

Cocaine

CREB1

cAMP responsive element binding protein 1

Cocaine

CREB5

cAMP responsive element binding protein 5

Cocaine

FOSB

FBJ murine osteosarcoma viral oncogene homolog B

Cocaine

JUN

Jun proto-oncogene

Cocaine

NFKB1

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Cocaine

RELA

V-rel reticuloendotheliosis viral oncogene homolog A (avian)