Figure 2

Elimination of CCR7 in comprehensive screening of juvenile mice diminishes enormous healing potential. (A,B) Representative images of the patellar groove surface in juvenile WT, CCR7^−/− mice with safranin O staining, H&E staining and immunostaining for type II collagen at 4 and 8 weeks postoperatively (n = 10/each group). Scale bar: 100 µm. (C,D) Representative images of the patellar groove surface in adult WT, CCR7^−/− mice with safranin O staining, H&E staining and immunostaining for type II collagen at 4 and 8 weeks postoperatively (n = 10/group). Scale bar: 100 µm. (E,F) Histological scores in juvenile and adult WT, CCR7^−/− mice at 4 and 8 weeks postoperatively (n = 10/group). Repair scoring range: 0–14. All values are expressed as mean ± SD (n = 10/group). **P < 0.01, statistically significant (Steel-Dwass test).