Table 2 Tumor and tumor samples properties.

From: Improved survival prognostication of node-positive malignant melanoma patients utilizing shotgun proteomics guided by histopathological characterization and genomic data

Samples’ properties:

mean

sd

min

max

tumor %

66

33

0

99

necrosis %

5

11

0

63

lymph node %

12

23

0

97

connective tissue %

17

26

0

100

Tumor properties

n

%

 

tumor cell size

<20 microns

98

88

 

20–25 microns

2

2

 

>25 microns

1

1

 

tumor cell shape

epithelioid

82

74

 

mixed epithelioid and spindle

17

15

 

spindle

2

2

 

Tumor cell pigmentation

0

48

43

 

1

20

18

 

2

13

12

 

3

20

18

 

Lymphocyte density

0

17

15

 

1

37

33

 

2

33

30

 

3

11

10

 

Lymphocyte distribution

0

17

15

 

1

35

32

 

2

25

23

 

3

21

19

 

Immunoscore,  = sum of lymphocyte density and distribution

0

15

14

 

1

3

3

 

2

24

22

 

3

18

16

 

4

16

14

 

5

16

14

 

6

6

5

 
  1. Tumor cell pigmentation (0 = absent: no melanin pigment discernible even at high power magnification, 1 = slight: melanin pigmentation hardly visible at low power, at high power, melanocytes show a faint diffuse hue or a few scattered melanin pigment granules, 2 = moderate: pigmentation visible at low power, the cytoplasm is translucent and appears significantly lighter than the hematoxylin stained nuclei, 3 = high: pigmentation is easily visible at low power, the cytoplasmic pigmentation reaches an intensity approximating that of the nucleus).
  2. Lymphocyte distribution (0 = no lymphocytes within the tissue, 1 = lymphocytes present involving <25% of the tissue cross sectional area, 2 = lymphocytes present in 25 to 50% of the tissue, 3 = lymphocytes present in >50% of tissue).
  3. Lymphocyte density (0 = absent, 1 = mild, 2 = moderate, 3 = severe).
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