Figure 1

Phylogenetic relationships within species Enterovirus A. Maximum likelihood phylogenetic tree of reference genomes in the species Enterovirus A, and representative sub-genotype sequences of EV-A71, using the General Time Reversible model. A discrete Gamma distribution was used to model evolutionary rate differences among sites (5 categories, shape parameter = 0.5488). Bootstrap values are displayed at nodes. Red triangle: known virus causing HFMD. Scale: substitutions per site.