Table 1 Pairwise genetic distances between viruses of species Enterovirus A and subtypes of EV-A71.

From: A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence

 

A

B0

B1

B2

B3

B4

B5

C1

C2

C3

C4

C5

A16

AB575911 EV-A71/B0

0.32

            

AB575913 EV-A71/B1

0.31

0.17

     

B

0.17

    

AB575927 EV-A71/B2

0.31

0.20

0.10

    

C

0.19

    

DQ341367 EV-A71/B3

0.32

0.23

0.20

0.17

      

B

C

 

DQ341366 EV-A71/B4

0.33

0.23

0.16

0.10

0.17

    

A

0.32

0.33

 

KF974781 EV-A71/B5

0.32

0.23

0.17

0.12

0.19

0.09

   

B

 

0.30

 

AB575935 EV-A71/C1

0.32

0.29

0.30

0.31

0.30

0.31

0.31

      

AB575939 EV-A71/C2

0.33

0.29

0.31

0.31

0.31

0.32

0.31

0.10

     

DQ341356 EV-A71/C3

0.33

0.30

0.30

0.32

0.32

0.31

0.32

0.12

0.11

    

EU131776 EV-A71/C4

0.32

0.28

0.28

0.28

0.26

0.28

0.28

0.24

0.27

0.26

   

EU527983 EV-A71/C5

0.35

0.30

0.31

0.31

0.33

0.31

0.32

0.16

0.19

0.20

0.27

  

MG182694 CV-A16

0.35

0.39

0.39

0.40

0.42

0.40

0.42

0.41

0.43

0.43

0.42

0.42

 

AF326750 Baboon A13

0.89

0.87

0.86

0.85

0.84

0.88

0.87

0.89

0.91

0.88

0.85

0.85

0.86

  1. Genetic distances, in substitutions per site, calculated using the TN93 substitution matrix with sitewise rate variation modelled using a gamma distribution (shape parameter = 0.6868), between EV-A71 sub-genotypes, coxsackie virus CV-A16 (their nearest non-EV-A71 relative in Enterovirus A) and baboon A13, the outlier within Enterovirus A (see Fig. 1). The upper inset table shows the mean genetic distance within genotypes B and C, and the lower inset table shows the mean genetic distances between genotypes.
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