Figure 6
Less autoimmune reaction of intratumoral injection route. Auto-reactive T cell activation by the administration of DTA-1 Ab. DTA-1 Ab was injected into the CT26 subcutaneous tumor (IT) or into the peritoneum (IP), and 7 days later splenocytes and lymphocytes from TDLNs were co-cultured with syngeneic splenocytes. Nonspecific T cell activation was detected by IFN-γ-ELISpot assay (n = 3). P values for DTA-1 IP vs IT, as analysed by t-test.
