Table 2 Comparison of dose-adjusted mean trough concentrations of lenvatinib between genotypes of ABC transporters and CYP3A4/5.
Genotype | n | Dose-adjusted C0 (ng/mL/mg) | P value | |
|---|---|---|---|---|
Median | Minimum - Maximum | |||
ABCB1 1236C > T | ||||
C/C | 8 | 4.37 | (1.67–10.4) | 0.303a |
C/T | 22 | 5.87 | (1.40–12.6) | |
T/T | 10 | 5.85 | (3.24–11.0) | |
ABCB1 2677G > T/A | ||||
G/G | 9 | 5.08 | (3.09–12.6) | 0.755a |
G/T + G/A | 19 | 5.67 | (1.40–11.0) | |
T/T + T/A + A/A | 12 | 5.62 | (2.06–11.0) | |
ABCB1 3435C > T | ||||
C/C | 14 | 4.90 | (1.40–12.6) | 0.724a |
C/T | 21 | 5.52 | (2.06–11.0) | |
T/T | 5 | 6.02 | (4.24–7.46) | |
ABCG2 421C > A | ||||
C/C | 20 | 4.73 | (1.40–12.6) | 0.063b |
C/A + A/A | 20 | 6.34 | (1.67–10.4) | |
ABCC2 −24C > T | ||||
C/C | 24 | 5.03 | (1.40–12.6) | 0.036b |
C/T + T/T | 16 | 6.57 | (4.06–11.0) | |
CYP3A4 20230G > A(*1G) | ||||
*1/*1 | 24 | 6.34 | (1.40–12.6) | 0.018b |
*1/*1 G + *1 G/*1G | 16 | 4.77 | (1.67–7.52) | |
CYP3A5 6986 A > G(*3) | ||||
*1/*1 + *1/*3 | 14 | 4.77 | (1.67–10.4) | 0.063b |
*3/*3 | 26 | 6.22 | (1.40–12.6) | |
Sex | ||||
Female | 27 | 5.67 | (1.67–12.6) | 0.252b |
Male | 13 | 5.08 | (1.40–10.4) | |
Correlation coefficient (r) | ||||
Age (years) | 0.061 | 0.817 | ||
Body weight (kg) | −0.220 | 0.414 | ||
Laboratory test values at lenvatinib initiation | ||||
Aspartate transaminase | 0.273 | 0.098 | ||
Alanine transaminase | 0.151 | 0.388 | ||
Serum albumin | 0.189 | 0.249 | ||
Total bilirubin | 0.336 | 0.037 | ||
Serum creatinine | −0.151 | 0.357 | ||
