Table 3 Stepwise multiple regression analysis of explanatory variables for the dose-adjusted C0 of lenvatinibTable 3. Stepwise multiple regression analysis of explanatory variables for the dose-adjusted C0 of lenvatinib.

From: Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer

Explanatory variable

Slope

SE

SRC

P- value

R 2

 

0.226

CYP3A4 genotype (*1G allele = 1)

−2.05

0.75

−0.397

0.010

 

Total bilirubin (mg/dL)

3.67

1.77

0.300

0.046

 

Intercept = 

6.39

1.66

   
  1. C0, predose concentration.
  2. SE, standard error; SRC, standardized regression coefficient.
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