Figure 2 | Scientific Reports

Figure 2

From: Preventing lung pathology and mortality in rabbit Staphylococcus aureus pneumonia models with cytotoxin-neutralizing monoclonal IgGs penetrating the epithelial lining fluid

Figure 2

Prophylaxis by ASN100 improves the macroscopic lung pathology in necrotizing pneumonia. 24 hours prior to lethal intra-tracheal challenge with the S. aureus LAC strain rabbits intravenously immunized with ASN100 at indicated doses or placebo. Macroscopic lung tissue scores (A) and lung edema rates (LW/BW × 103) (B) of rabbits treated with ASN100 (1.25, 5, or 20 mg/kg) or placebo, evaluated at 12 hours post challenge. Individual animals are represented by open and closed symbols for the two independent studies and lines indicate the group mean values. P-values were calculated based on group-comparison by the Mann-Whitney test and are shown for all statistically different comparisons.

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