Figure 6 | Scientific Reports

Figure 6

From: Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer’s disease patients

Figure 6

Relative quantification of Aβ glycopeptides and peptides. (A) Quantification, L/H ratios, of Aβ1-15 (peptide fragments), of Galβ3GalNAcα-Aβ1-15 (peptide fragments and oxonium ions), and of Galβ3GalNAcα-Aβ1-17 (peptide fragments and oxonium ions) from 10 QC CSF samples analyzed together with the 40 patient samples. (B) Quantification of Aβ1-15, Galβ3GalNAcα-Aβ1-15 and Galβ3GalNAcα-Aβ1-17 using the same ratios as above for CSF samples of 20 AD patients and 20 matched healthy controls. The simultaneously measured ratios of Aβ1-17 peptide versus Aβ1-15** for the QC, AD and control samples are shown in Supplementary Fig. 7A.

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