Table 1 Rule comparison.

From: Regional gender differences in an autosomal disease result in corresponding diversity differences

No

Rule

Simpler Rule

P Value

1

{Sex = Female, HBA_CNV = AC03, HBB = B00} => {HBA2 = A203}

{Sex = Female} => {HBA2 = A203}

0.0252

2

{Sex = Female, HBA_CNV = AC03, HBB = B00} => {HBA2 = A203}

{HBB = B00} => {HBA2 = A203}

0.026

3

{Sex = Female, HBA_CNV = AC03, HBB = B00} => {HBA2 = A203}

{Sex = Female, HBB = B00} => {HBA2 = A203}

0.0346

4

{Sex = Male, Age = Y} => {HBB = B01}

{Age = Y} => {HBB = B01}

0.0332

5

{Sex = Male, HBA2 = A200, HBA_CNV = AC00} => {HBB = B04}

{HBA2 = A200} => {HBB = B04}

0.0484

6

{Sex = Male, Age = O, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{Age = O} => {HBA_CNV = AC03}

0.0164

7

{Sex = Male, Age = O, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{HBA2 = A200} => {HBA_CNV = AC03}

0.0028

8

{Sex = Male, Age = O, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{HBB = B00} => {HBA_CNV = AC03}

0.0045

9

{Sex = Male, Age = O, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{Age = O, HBA2 = A200} => {HBA_CNV = AC03}

0.0177

10

{Sex = Male, Age = O, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{Age = O, HBB = B00} => {HBA_CNV = AC03}

0.0251

11

{Sex = Male, Age = O, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

0.0044

12

{Sex = Male, Age = O, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{Age = O, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

0.0442

13

{Sex = Male, Age = O, HBB = B00} => {HBA_CNV = AC03}

{Age = O} => {HBA_CNV = AC03}

0.0236

14

{Sex = Male, Age = O, HBB = B00} => {HBA_CNV = AC03}

{HBB = B00} => {HBA_CNV = AC03}

0.0089

15

{Sex = Male, Age = O, HBA2 = A200} =>{HBA_CNV = AC03}

{Age = O} => {HBA_CNV = AC03}

0.0291

16

{Sex = Male, Age = O, HBA2 = A200} => {HBA_CNV = AC03}

{HBA2 = A200} => {HBA_CNV = AC03}

0.0077

17

{Sex = Male, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{HBA2 = A200} => {HBA_CNV = AC03}

0.0041

18

{Sex = Male, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{HBB = B00} => {HBA_CNV = AC03}

0.0101

19

{Sex = Male, HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

{HBA2 = A200, HBB = B00} => {HBA_CNV = AC03}

0.0098

20

{Sex = Male, HBB = B00} => {HBA_CNV = AC03}

{HBB = B00} => {HBA_CNV = AC03}

0.0126

21

{HBA2 = A200, HBA_CNV = AC03} => {Sex = Male}

{HBA2 = A200} => {Sex = Male}

0.0183

  1. Because “Sex” was thought to be essential in Xishuangbanna, a permutation test was applied to the significant rules with “Sex” (see Method). The most concerned three rules are {Sex = Male} => {HBA_CNV = AC03}, {Sex = Male, Age = O} => {HBA_CNV = AC03}, and {Sex = Male, Age = Y} => {HBB = B01}. After shuffling “Sex”, the proportions of their Fisher test p values less than 0.01 were 9e-04, 4e-04, 1e-03, respectively; the proportion of p values less than 0.03 were 0.0011 0.0019 0.0066, respectively; the proportion of p values less than 0.05 were 0.0019 0.0067 0.0129, respectively (see PermutationTestBN in S1_Table.xls). These proportions suggest that, “Sex” certainly relates to “AC03” and “B01”.
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