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Figure 1

From: Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders

Figure 1

Neuroanatomy of Negr1 in adult mouse brain. Expression of Negr1 by in situ hybridisation in adult sagittal brain sections (a,b). OB olfactory bulb, Pir piriform cortex, OT olfactory tubercle, iSI island of Calleja, Th thalamus, Amy amygdala, Sub subiculum, DG dentate gyrus, IGL inter geniculate lateral geniculate complex, CP caudate putamen, MO somatomotor cortex, SS somatosensory cortex, PTLP posterior parietal association area, VIS visual area, Epd endopiriform cortex, HA hypothalamus, Cb cerebellum, RsPD retrosplenial cortex, CLA claustrum, RT reticular nucleus of thalamus, LGD/V dorsal/ventral part of lateral geniculate complex, MG medial geniculate nucleus. Gross cytoarchitecture shown by neurofilament immunostaining in Wt (c), enlarged ventricles in Negr1−/− mice brain (d), LV lateral ventricles. A 3D reconstruction of the Wt (e) and Negr1−/− (f) mice brains and ventricles (green: lateral ventricles, yellow: third ventricle and purple: fourth ventricle) in Wt (g) and Negr1−/− (h) brains. Ventricle enlargement is observed in the Negr1−/− mice. Quantitative analysis of effects of Negr1 deletion in mice on the volume of total brain (i), lateral ventricles (j), third ventricles (k), corpus callosum (l), globus pallidus (m) and in hippocampus (n). Data represent mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, Mann-Whitney U test (Wilcoxon rank sum test).

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