Table 1 Weight (g) and volume (mm3) measurements (mean ± SEM) of selected regions in the Negr1−/− compared to the corresponding Wt. P values as determined by Mann-Whitney U test (Wilcoxon rank sum test). (Bold p-value means significant difference as *p < 0.05; **p < 0.01, ***p < 0.001).
Wt | Negr1 −/− | % Diff | P-value | |
|---|---|---|---|---|
Body weight (g) | 32.7 ± 3.6 | 31.2 ± 5 | −4.7 | 0.32 |
Brain weight | 0.45 ± 0.022 | 0.45 ± 0.028 | −0.6 | 0.88 |
Total brain volume (mm3) | 493.2 ± 21.5 | 465 ± 20.4 | −5.7 | 0.03 |
White matter regions (mm 3 ) | ||||
Corpus callosum | 15.71 ± 1.5 | 13.24 ± 2.1 | −15.7 | 0.04 |
Ant commissure (anterior) | 1.4 ± 0.15 | 1.3 ± 0.2 | −8.9 | 0.31 |
Ant commissure (posterior) | 0.35 ± 0.9 | 0.36 ± 0.06 | 1.9 | 0.77 |
Internal capsule | 2.1 ± 0.5 | 1.9 ± 0.56 | −10.18 | 0.31 |
Fornix | 0.49 ± 0.07 | 0.45 ± 0.06 | −7.83 | 0.47 |
Fimbria | 1.8 ± 0.33 | 1.7 ± 0.21 | −4.7 | 0.47 |
Ventricles (mm 3 ) | ||||
Lateral Ventricle | 1.5 ± 0.22 | 2.47 ± 0.73 | 64.6 | 0.002 |
3rd Ventricle | 0.54 ± 0.05 | 0.74 ± 0.18 | 37 | 0.02 |
4th Ventricle | 0.14 ± 0.02 | 0.19 ± 0.06 | 35.7 | 0.06 |
Cortical and sub-cortical grey matter regions (mm 3 ) | ||||
Olfactory system | 33.5 ± 2.9 | 32.9 ± 2.1 | −1.9 | 0.66 |
Frontal cortex | 52.6 ± 6.5 | 48.3 ± 2.8 | −8.2 | 0.11 |
Striatum | 18.5 ± 1.2 | 17.7 ± 1.2 | −4.2 | 0.19 |
Globus pallidus | 2.2 ± 0.5 | 1.9 ± 0.18 | −15.5 | 0.03 |
Hippocampus | 23.2 ± 1.6 | 20.8 ± 2.4 | −10 | 0.02 |
Thalamus | 15.2 ± 0.9 | 15.1 ± 1.5 | −1.04 | 0.77 |
Hypothalamus | 10.3 ± 0.7 | 9.9 ± 0.6 | −4.21 | 0.47 |
Midbrain | 8.8 ± 0.5 | 9.0 ± 1.2 | 2.03 | 0.66 |
Pons | 16.7 ± 1.8 | 15.3 ± 1.5 | −8.3 | 0.31 |
Medulla | 21.0 ± 3.2 | 22.7 ± 3.7 | 8.16 | 0.39 |
Cerebellum | 55.3 ± 1.9 | 57.5 ± 2.1 | 3.99 | 0.19 |
