Table 2 Negr1−/− mice display alterations in social interactions and non-social interest. Social interaction scores during male-male direct interaction, marbles burying test (b) and tail suspension test (c). Data represent mean ± SEM and bold numbers represent significant differences, s (seconds), Mann–Whitney U test (Wilcoxon rank sum test).
Direct-Social Interaction test | ||||
|---|---|---|---|---|
Parameter | Genotype | Total no of bouts | Time (s) | Bout duration (s) |
Sum of total social contact | Wt | 73 ± 14.7 | 134.8 ± 72 | 2.2 ± 4.9 |
Negr1 −/− | 87.5 ± 11.5 | 123.9 ± 32.9 | 1.5 ± 2.9 | |
Active contact | Wt | 56.8 ± 15.2 | 81.4 ± 30 | 1.5 ± 2 |
Negr1 −/− | 64.7 ± 14 | 81.1 ± 23.8 | 1.3 ± 1.7 | |
Anogenital sniffing | Wt | 23 ± 9.3 | 34 ± 22.2 | 1.3 ± 1.6 |
Negr1 −/− | 28 ± 9.2 | 37.3 ± 18.1 | 1.2 ± 0.3 | |
Sniffing (other body parts) | Wt | 38 ± 9 | 52.4 ± 10.7 | 1.3 ± 0.3 |
Negr1 −/− | 42 ± 7 | 49.5 ± 11.5 | 1.1 ± 0.1 | |
Passive contact | Wt | 18 ± 3.6 | 54.6 ± 83 | 2.8 ± 3.5 |
Negr1 −/− | 25 ± 12.4 | 46 ± 41 | 1.5 ± 0.6 | |
Digging | Wt | 29 ± 9.9 | 65 ± 34.3 | 2.1 ± 0.9 |
Negr1 −/− | 46 ± 10.2 | 91 ± 27.6 | 1.8 ± 0.3 | |
Rearing | Wt | 31 ± 10.9 | 5.9 ± 2.2 | 0.2 ± 0.1 |
Negr1 −/− | 25 ± 10.2 | 19.4 ± 16.9 | 0.7 ± 0.5 | |
Self-grooming | Wt | 12 ± 4.1 | 45.6 ± 20 | 3.5 ± 1 |
Negr1 −/− | 7 ± 3.6 | 25.4 ± 16.5 | 3.4 ± 1.8 | |
Marble-burying test {Number of marble buried/displaced in 30 min} | Wt | 6.15 ± 3.55 | ||
Negr1 −/− | 4.43 ± 2.6 | |||
Tail-suspension test {Immobility time duration (s)} | Wt | 133 ± 25.4 | ||
Negr1 −/− | 118 ± 32.7 | |||
