Figure 2

Effect of CED of cisplatin on survival of GL261 tumour-bearing C57BL/6 mice. Kaplan-Meier survival curves of GL261-bearing mice receiving CED of cisplatin using a mini-osmotic pump/brain infusion kit at days 7–9, 0.01 μg/μl/h (n = 23) and non-treated mice (n = 41). The survival rate of treated mice was 39%; 1 mouse was excluded from the graph due to signs of toxicity of cisplatin on day 14. Non-treated vs. cisplatin (****p < 0.0002), log rank test. Survival was monitored for 100 days.