Figure 3

Effect of CED of cisplatin on survival of GL261 tumour-bearing NSG mice. Kaplan-Meier survival curves of GL261-bearing mice receiving CED of cisplatin using a mini-osmotic pump/brain infusion kit at days 7–9, 0.01 μg/μl/h (n = 6) or non-treated mice (n = 6); 1 mouse was excluded from the graph due to signs of toxicity of cisplatin on day 17. No significant difference was found between treated and non-treated mice (non-treated vs. cisplatin, p = 0.1943), log rank test. Survival was monitored for 100 days.