Table 1 Pathogenicity of GP-expressing recombinant viruses in embryonated eggs and 1-day-old chicks.

From: Novel avian paramyxovirus-based vaccine vectors expressing the Ebola virus glycoprotein elicit mucosal and humoral immune responses in guinea pigs

Virus

MDTa (h)

rNDV-3FH WT

>114

rAPMV-3 N/P-GP

>168

rNDV-3FH N/P-GP

>168

Virus

ICPI b

rNDV-3FH WT

0.08

rAPMV-3 N/P-GP

0.63

rNDV-3FH N/P-GP

0.51

  1. aMean embryo death time (MDT): the mean time (h) for the minimum lethal dose of virus to kill all of the inoculated embryos42. Pathotype definition: virulent strains, <60 h; intermediate virulent strains, 60 to 90 h; avirulent strains, >90 h.
  2. bIntracerebral pathogenicity index (ICPI): evaluation of disease and death following intracerebral inoculation in 1-day-old SPF chicks42. Pathotype definition: virulent strains, 1.5–2.0; intermediate virulent strains, 0.7–1.5; and avirulent strains, 0.0–0.7.
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