Figure 7
From: Integrative analysis identifies lincRNAs up- and downstream of neuroblastoma driver genes
Identification of lincRNAs as modulators of activity or expression of driver genes. (a) Schematic representation of the investigated lincRNAs, modulating the activity of the effector proteins, MYCN and PHOX2B. The circular plots display the number of lincRNAs, expressed in NB cell lines, found to be modulators of MYCN and PHOX2B targets. Bar plots show the top 5 hallmarks that were significantly enriched (Fisher exact test, p < 0.001). (b) The heatmap visualizes the clustering of the significantly enriched hallmarks for the top 20 modulating lincRNAs. (c) Differences in distance correlation between the samples of low and high abundance of the lincRNAs. The presented targets are genes enriched in the hallmark gene sets. (d) Schematic representation of the investigated lincRNAs, regulating the activity of the target protein MYCN. The circular plots display the number of activating and inhibiting lincRNAs modulating MYCN expression. The top 5 effectors targeting MYCN are shown in the bar plot. (e) Clustering of the top 20 regulating lincRNAs with MYCN as target is visualized in the heatmap.
