Figure 4
From: Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic
Observed mechanism of translation inhibition by cadazolid. (a) Overlay of an A-site tRNA (PDB 1VY451) (light green) and CDZ (orange). Ring B and the fluoroquinolone moiety clash with an aminoacylated A-site tRNA, thereby preventing binding. (b) The two observed conformations of A2602. The fluoroquinolone moiety stacks with the “flipped-out” conformation to stabilize the PTC in a post-translocation conformation. (c,d) Schematic representation of the PTC with an A-site tRNA (c) or CDZ (d).
