Table 1 In vitro transcription/translation assays for cadazolid and linezolid against E. coli wt ATCC 25922; S. aureus wt ATCC 29213; S. aureus S1 (LZDR). The minimal inhibitory concentrations are also shown.

From: Structural basis of translation inhibition by cadazolid, a novel quinoxolidinone antibiotic

 

Cadazolid

Linezolid

E. coli ATCC 25922

Average (range)a

0.24 (0.13–0.34)

4.03 (1.92–5.39)

MICb

8/< = 0.063c

>32/8d

S. aureus ATCC 29213

Average (range)

0.32 (0.31–0.35)

2.61 (1.12–4.15)

MIC

0.5

2

S. aureus S1 LZDR d

Average (range)

0.33 (0.25–0.44)

7.03 (6.16–9.16)

MICc

1

32

  1. aIC50 in µM (average value and range of three independent experiments).
  2. bMIC in µg/ml (median value of at least 3 determinations).
  3. cMeasured against E. coli MG1655 tolC::kan.
  4. dHomozygous G2576U in 23S rRNA.
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