Figure 3

Percentage of proliferation in thyroid follicular cells of WT and IRS2-KO mice of both sexes. The plots show the comparison between wild-type (WT) and IRS2 deficient animals (KO), regarding the gender and regions of the gland (MM: male marginal; MC: male central; FM: female marginal; FC: female central), and the values are expressed as mean ± SEM. (a) Graphic showing the percentage of proliferation by PCNA-positive follicular cells. Significant differences are defined as: ^* p < 0.01 with respect to WT MM; ^**p < 0.01 with respect to WT MC and KO MM, and p < 0.05 with respect to KO FC; #p < 0.05 with respect to FM. (b) Plot showing the percentage of proliferation by Ki67-positive follicular cells. Statistically different at: ^* p < 0.05 with respect to WT MM and KO FM; ^**p < 0.01 with respect to WT MC, KO MM and KO FC; #p < 0.05 with respect to FM.