Figure 4
From: The influence of the lack of insulin receptor substrate 2 (IRS2) on the thyroid gland
Immunohistochemical reaction for active caspase-3 and TUNEL assay in thyroid follicular cells. Follicular active caspase 3-positive cells in WT female (A) and male animals (D), and IRS2-KO female (B–C arrows) and male (E–F arrows) mice. TUNEL-positive follicular cells were less numerous in the WT female (G) and male (I) mice than in the IRS2-KO female (H, arrows) and male (J, arrows) animals. Scale bars: A, B, D, E = 60 µm; C, F = 20 µm; G–J = 12 µm.
