Figure 5

Percentage of apoptosis in thyroid follicular cells of WT and IRS2-KO mice of both sexes. The plots show the comparison between wild-type (WT) and IRS2 deficient animals (KO), regarding the gender and regions of the gland (MM: male marginal; MC: male central; FM: female marginal; FC: female central), and the values are expressed as mean ± SEM. (a) Graphic showing the percentage of apoptosis by active caspase-3-positive follicular cells. Significant differences are defined as: ^*p < 0.01 with respect to WT MM, ^**p < 0.01 with respect to WT MC and KO MM; #p < 0.01 with respect to WT FM and KO MM; ##p < 0.01 with respect to WT FC, KO FM and KO MC. (b) Plot showing the percentage of apoptosis by TUNEL-positive follicular cells. Significant differences are defined as: ^*p < 0.05 with respect to WT MM; ^**p < 0.01 with respect to WT MC and KO MM; #p < 0.05 with respect to WT FM; ##p < 0.01 with respect to WT FC and KO FM and p < 0.05 with respect to KO MC.