Table 1 Left ventricular hemodynamic indices derived from PV loop analysis.
From: Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice
Sham (n = 6) | 25G (n = 10) | 26G (n = 10) | 27G (n = 7) | P-value | |
|---|---|---|---|---|---|
Pressure-Volume Haemodynamic Measurements (Day 28) | |||||
Cardiac Output (mL/min) | 12.1 ± 1.67 | 12.8 ± 1.16 | 8.56 ± 0.87 | 8.08 ± 1.89 | 0.0299 |
Stroke Volume (µL) | 21.5 ± 3.00 | 23.1 ± 2.01 | 15.7 ± 1.64 | 14.7 ± 3.53 | 0.0415 |
Stroke Work (µL*mmHg) | 1767 ± 247 | 2330 ± 233 | 1510 ± 188 | 1236 ± 368† | 0.0229 |
Heart Rate (bpm) | 558.7 ± 9.33 | 557.9 ± 12.43 | 550.2 ± 11.61 | 551.3 ± 7.026 | 0.9323 |
dP/dt Max vs. EDV | 181.6 ± 32.9 | 160.8 ± 55.3 | 74.13 ± 15.8 | 49.13 ± 4.62 | 0.0759 |
Emax | 8.42 ± 1.21 | 12.8 ± 2.99 | 8.57 ± 2.10 | 5.79 ± 0.93 | 0.2364 |
ESPVR | 2.78 ± 0.43 | 4.31 ± 0.96 | 3.18 ± 0.59 | 2.51 ± 0.17 | 0.3238 |
EDPVR | 0.30 ± 0.07 | 0.42 ± 0.12 | 0.69 ± 0.24 | 1.03 ± 0.49 | 0.2613 |
Effective Arterial Elastance (mmHg/µL) | 5.33 ± 1.09 | 7.00 ± 1.45 | 12.5 ± 3.17 | 12.0 ± 2.41 | 0.113 |
Aortic Systolic Pressure (mmHg) | 102.0 ± 1.71 | 140.6 ± 6.69** | 160.6 ± 7.64*** | 148.3 ± 3.44*** | <0.0001 |
Aortic Diastolic Pressure (mmHg) | 69.8 ± 1.91 | 69.5 ± 2.52 | 66.9 ± 2.71 | 64.4 ± 1.23 | 0.4385 |
Aortic Pulse Pressure (mmHg) | 32.2 ± 1.45 | 71.2 ± 5.35*** | 93.7 ± 5.84***,† | 83.9 ± 3.29*** | <0.0001 |
