Table 2 Comparison of mild (25G), moderate (26G) and severe (27G) TAC in mice. HFrEF: heart failure with reduced ejection fraction.
From: Distinct Phenotypes Induced by Three Degrees of Transverse Aortic Constriction in Mice
Component | 25G TAC | 26G TAC | 27G TAC |
|---|---|---|---|
Survival | 100% | 100% | 84% |
Pressure Overload (TAC Gradient) | 60.2 ± 5.6 mmHg (Mild) | 85.5 ± 4.4 mmHg (Moderate) | 106.6 ± 5.2 mmHg (Severe) |
LV Hypertrophy (weight vs. sham) | 27.8 ± 4.79% (Mild) | 53.5 ± 7.39% (Moderate) | 60.4 ± 5.83% (Severe) |
Systolic Dysfunction (Echocardiography) | None | Strain only (Mild) | Global and strain (Severe) |
Diastolic Dysfunction (Echocardiography) | Moderate | Moderate | Severe |
Systolic Dysfunction (PV Loops) | None | Moderate | Severe |
Diastolic Dysfunction (PV Loops) | Very mild | Moderate | Severe |
Cardiac Fibrosis | None | Perivascular only (Mild) | Perivascular and interstitial (Severe) |
Increased Lung Weight (% of total mice) | 8% (Very mild) | 25% (Mild) | 45% (Moderate) |
Elevated Plasma BNP (% of total mice) | 14% (Mild) | 71% (Moderate) | 100% (Severe) |
Renal Atrophy | None | None | 8.65 ± 1.57% (Mild) |
Proposed Disease Phenotype Correlate | Hypertensive Heart Disease | Early Decompensation | HFrEF |
