Table 1 Phenotype of JO4 derivatives.

From: Structure-based Design of JOC-x, a Conjugatable Tumor Tight Junction Opener to Enhance Cancer Therapy

Protein

DSG2 binding

VIA IC50 (µg/mL)

JO-4

Yes

0.067

GB1

Yes

0.025

GB2

Yes

0.030

GB3

Yes

0.029

GB4

Yes

0.037

GB5

Minimal

0.241

GB6

n/a

n/a

GB7/JOC-x

Yes

0.032

GB8

Yes

0.012

GB9

No

>10

GB10

Yes

0.026

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