Figure 1 | Scientific Reports

Figure 1

From: Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis

Figure 1

IPF lung fibroblasts showed increased sensitivity to TGF-β1-stimulated PAI-1 release. Time course of PAI-1 release from non-stimulated (A) and TGF-β1-stimulated (B) fibroblasts derived from control (white) and IPF (grey) patients. PAI-1 release from control (C) and IPF (D) fibroblasts at 72 h following exposure to the indicated TGF-β1 concentrations. Data represents the mean +/− SEM of five individuals. Statistical significance was performed using 1-way analysis of variance (ANOVA) with a Dunnett’s test for time courses (A,B) where *p < 0.05, **p < 0.01, ***p < 0.001 and ***p < 0.0001. The logEC50 for each individual was determined in GraphPad Prism and comparison between control and IPF groups was performed using a unpaired t-test. The EC50 was calculated from the mean logEC50 values.

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