Figure 2 | Scientific Reports

Figure 2

From: Novel screening system revealed that intracellular cholesterol trafficking can be a good target for colon cancer prevention

Figure 2

Primary screening of validated library based on the decrease of TCF/LEF- and NF-κB-luciferase activity and increase of NRF2-luciferase activity. Relative luciferase activity was evaluated 24 hours after adding each compound in the validated library at 1 μM in HCT116 (A) and DLD-1 (B) reporter cell lines. Relative luciferase activities of TCF/LEF, NF-κB and NRF2 in the cells treated with each compound (X-axis) are plotted from ascending TCF/LEF activity (Y-axis). The data are shown as relative values, with the value from vehicle-treated cells set as 1 in each cell lines.

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