Table 1 Hit compounds selected by the first screening.
Drugs | Original uses | Relative luciferase activity | Cell lines | ||
|---|---|---|---|---|---|
TCF/LEF | NF-κB | NRF2 | |||
Alexidine dihydrochloride | Antibacterial | 0.16 | 0.62 | 1.60 | HCT116 |
Benzethonium chloride | Antibacterial | 0.51 | 0.65 | 1.53 | HCT116 |
Bortezomib | Antineoplastic | 0.40 | 0.22 | 23.87 | DLD1 |
Docetaxel | Antineoplastic | 0.38 | 0.41 | 1.52 | DLD1 |
Exemestane | Antineoplastic | 0.65 | 0.78 | 3.28 | HCT116 |
Fenbendazole | Anti-intestinal parasites | 0.59 | 0.77 | 1.46 | DLD1 |
Itraconazole | Antifungal | 0.53 | 0.70 | 1.21 | HCT116 |
Pyrvinium pamoate | Anthelmintic | 0.02 | 0.30 | 3.34 | HCT116 |
