Figure 3
From: RNA recognition motifs of disease-linked RNA-binding proteins contribute to amyloid formation
RRMs from TDP-43 and FUS form fibrillar aggregates. Solutions of TDP-43 RRM1 (50 μM) and FUS RRM (50 μM) were agitated in the presence of 10 mM phosphate (pH 7.5) and 50 mM NaCl in room temperature. The freshly-formed fibrillar solutions were examined under negative-stain transmission electron microscopy (EM) to reveal fibril-like aggregates.
