Figure 7 | Scientific Reports

Figure 7

From: Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes

Figure 7

Effect of Mixture S on circulating Testosterone (T), Estradiol (E2) and Luteinizing hormone (LH) levels of PND90 male (a–c) and female (e,f) offspring exposed to 0x (DMSO), 10x, 100x and 500x SELMA mothers’ levels. In (d) the percentage of males per group exhibiting a T/E2*100 value lower than the threshold of 10 (dashed horizontal line) is indicated. Bars represent the estimated marginal means ± SE. Number of males used for T, E2 and LH: 8–16, 7–13 and 3–11, respectively. Number of females used for E2 and LH: 5–13 and 3–6, respectively. Samples of siblings were pooled for LH. In females, the phase of the estrous cycle was included as covariate in statistics. ¤p < 0.01.

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