Table 2 Reproductive indices of male and female offspring.

From: Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes

AGD/cubic root of BW

DMSO

10x

100x

500x

 

Males

PND1

1.41 ± 0.02

(34)

1.52 ± 0.04

(14)

1.42 ± 0.03

(19)

1.37 ± 0.03

(26)

PND21

3.81 ± 0.04

(30)

3.61 ± 0.07*

(13)

3.56 ± 0.05¤

(19)

3.79 ± 0.04

(26)

PND90

6.42 ± 0.05

(21)

6.16 ± 0.08*

(8)

6.43 ± 0.07

(12)

6.41 ± 0.06

(13)

 

Females

PND1

0.93 ± 0.02

(26)

1.06 ± 0.03#

(15)

0.98 ± 0.02

(14)

0.94 ± 0.02

(16)

PND21

2.29 ± 0.03

(24)

2.13 ± 0.04¤

(17)

2.01 ± 0.04#

(14)

2.27 ± 0.04

(12)

PND90

3.26 ± 0.03

(14)

3.18 ± 0.04

(9)

3.24 ± 0.04

(9)

3.24 ± 0.04

(9)

Gonad weight/BW

DMSO

10x

100x

500x

 

Males

PND21

3.05 ± 0.04

(11)

3.21 ± 0.06

(5)

2.85 ± 0.06*

(7)

2.90 ± 0.05

(9)

PND90

4.41 ± 0.06

(21)

4.35 ± 0.09

(7)

4.28 ± 0.07

(12)

4.28 ± 0.07

(10)

 

Females

PND21

0.90 ± 0.29

(10)

0.87 ± 0.03

(8)

0.65 ± 0.04#

(5)

0.84 ± 0.04

(5)

PND90

1.18 ± 0.056

(14)

0.89 ± 0.07

(9)

0.78 ± 0.07#

(9)

1.15 ± 0.06

(9)

  1. AGD/cubic root of BW and gonad weight/BW values for postnatal day (PND) 1, 21 and 90 male and female offspring exposed to DMSO or to 10x, 100x and 500x of SELMA mothers’ levels for the chemicals in Mixture S. In the statistics of gonad weight/bw, the phase of the estrous cycle of PND90 females was included as covariate. Values represent estimated marginal means ± SE. The number of animals is given in parentheses. *p < 0.05; ¤p < 0.01; #p < 0.001 vs. DMSO.
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