Figure 5 | Scientific Reports

Figure 5

From: Early and Pre-Clinical Detection of Prion Seeding Activity in Cerebrospinal Fluid of Goats using Real-Time Quaking-Induced Conversion Assay

Figure 5

Time course of prion seeding activity detected in CSF of L-BSE-infected goats after intracerebral inoculations. (A) Prion seeding activities detected in CSF samples collected at 926 days post inoculum (dpi), 1080 dpi, 1200 dpi, and at clinical onset from L-BSE-infected goat G5. (B) Log SD50 analysis of CSF collected from-L-BSE infected goats (G5, G6 and G7) at different time points of asymptomatic stage as indicated in Table 2. Spearman-Karber analysis of the data was used to calculate the dilution of pure CSF required to give 50% positive replicate wells under IQ-CSF conditions (the 50% seeding dose [SD50]). Data are displayed as the mean + the standard deviation.

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